Depression is a profound and overwhelming struggle that affects millions of people worldwide. It can cloud one’s mind, create feelings of hopelessness, and make even the simplest tasks seem impossible. During these dark moments, it can feel as though God is distant or even absent. However, the Bible offers comfort, hope, and guidance for those walking through the valley of depression.
In the midst of despair, it is crucial to remember that God’s Word speaks directly to the brokenhearted and those who feel crushed by life’s burdens. Scriptures remind us that God is present, offering peace, strength, and healing, even when the weight of depression feels unbearable. The Bible contains promises that can anchor us during these difficult times, giving us the assurance that God understands our pain and will never abandon us.
This article provides 30 carefully selected Bible verses and prayers tailored to address various aspects of depression, from battling overwhelming sadness to seeking peace, comfort, and restoration. Each prayer is a heartfelt cry to God, coupled with a Scripture verse that reassures us of His presence and power. As you read and pray through these verses, may you find solace in the knowledge that you are not alone in this journey. God’s love, grace, and healing are available to you, and He can lift you out of the depths of despair into a place of peace, hope, and renewed strength.
35 Powerful Bible Verses During Depression in 2025
1. Bible Verse for Comfort in Loneliness
Dear Lord, in my moments of deep loneliness, I turn to You. I feel abandoned, but I know You are always with me. Please fill the void in my heart with Your presence and remind me that I am never truly alone. Help me find comfort in Your unfailing love and strength to continue, even when it feels impossible.
Psalm 34:18
“The Lord is close to the brokenhearted and saves those who are crushed in spirit.” Lord, draw near to me and heal my broken heart. Amen.
2. Bible Verse for Hope in Despair
Heavenly Father, when I feel overwhelmed by despair, remind me that You are my hope. Help me to cling to Your promises, knowing that You have plans to prosper me, even when I cannot see the way forward. Renew my hope, and let Your light shine through the darkness that surrounds me.
Jeremiah 29:11
“For I know the plans I have for you, declares the Lord, plans to prosper you and not to harm you, plans to give you hope and a future.” Guide me, Lord, towards Your future for me. Amen.
3. Bible Verse for Strength in Weakness
Father God, I feel so weak and burdened, unable to carry on. Yet, I trust that in my weakness, Your strength is made perfect. Empower me with Your divine strength to face each day. Grant me the endurance to overcome this season of depression and emerge stronger in You.
2 Corinthians 12:9
“My grace is sufficient for you, for my power is made perfect in weakness.” Lord, be my strength when I have none. Amen.
4. Bible Verse for Peace of Mind
Gracious Lord, my mind is overwhelmed by fear and worry. I ask for Your peace that surpasses all understanding to calm my anxious thoughts. Help me to rest in Your promises, knowing that You are in control and that I need not fear the future.
Philippians 4:6-7
“Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God. And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus.” Guard my mind with Your peace. Amen.
5. Bible Verse for Healing of the Soul
Lord Jesus, my soul feels heavy, burdened by sorrow and pain. I ask for Your healing touch upon my spirit. Restore the joy of my salvation, and heal every wound that depression has caused. May Your love mend the brokenness within me and bring renewal to my weary soul.
Psalm 147:3
“He heals the brokenhearted and binds up their wounds.” Heal my wounded heart, Lord. Amen.
6. Bible Verse for Joy Amidst Sadness
Heavenly Father, I struggle to find joy in the midst of my sadness. Remind me that true joy comes from You, even in difficult times. Help me to find glimpses of Your goodness each day, and restore the joy that only Your presence can bring to my life.
Psalm 30:5
“Weeping may stay for the night, but rejoicing comes in the morning.” Let Your joy return to my heart, Lord. Amen.
7. Bible Verse for Trust in God’s Plan
Lord, in the midst of depression, it’s hard to see Your plan for my life. I ask for the faith to trust in Your perfect will. Even when I don’t understand, help me to trust that You are working all things for my good, and guide me in Your ways.
Proverbs 3:5-6
“Trust in the Lord with all your heart and lean not on your own understanding; in all your ways submit to him, and he will make your paths straight.” I trust in Your divine plan, Lord. Amen.
8. Bible Verse for God’s Presence
Loving Father, when depression makes me feel distant from You, remind me that You are always near. Even in my darkest moments, You never leave me. Surround me with Your presence and help me feel the warmth of Your love, so I may draw closer to You.
Isaiah 41:10
“Do not fear, for I am with you; do not be dismayed, for I am your God. I will strengthen you and help you; I will uphold you with my righteous right hand.” Hold me close, Lord. Amen.
9. Bible Verse for Courage in the Face of Fear
Dear Lord, fear often overwhelms me during this battle with depression. Please fill my heart with courage and remind me that You are with me through every trial. Help me to stand strong, trusting that You will lead me through this storm with Your mighty hand.
Joshua 1:9
“Be strong and courageous. Do not be afraid; do not be discouraged, for the Lord your God will be with you wherever you go.” Strengthen my heart with courage. Amen.
10. Bible Verse for Rest for the Weary
Lord Jesus, I am weary and burdened by the weight of depression. I come to You seeking rest for my soul. Please give me the rest that only You can provide. Help me to lay my burdens at Your feet and trust You to carry them for me.
Matthew 11:28
“Come to me, all you who are weary and burdened, and I will give you rest.” Grant me Your divine rest, Lord. Amen.
10. Bible Verse for Rest for the Weary
Lord Jesus, I am weary and burdened by the weight of depression. I come to You seeking rest for my soul. Please give me the rest that only You can provide. Help me to lay my burdens at Your feet and trust You to carry them for me. Renew my strength so that I may continue to walk in Your light.
Matthew 11:28
“Come to me, all you who are weary and burdened, and I will give you rest.” I surrender my weariness to You, Lord. Amen.
11. Bible Verse for Faith in Uncertainty
Heavenly Father, depression clouds my vision and makes the future seem uncertain. Yet I place my trust in You, knowing that You hold every moment in Your hands. Strengthen my faith, Lord, so that I can rest in the assurance that You will never leave or forsake me, no matter how lost I may feel.
Hebrews 11:1
“Now faith is confidence in what we hope for and assurance about what we do not see.” Help me to walk in faith, trusting Your unseen plan. Amen.
12. Bible Verse for Refuge in God’s Presence
Lord, during this time of depression, I feel exposed and vulnerable. Help me find refuge in You, my shelter and safe place. Remind me that You are my strong tower, a place where I can rest securely. Surround me with Your presence, Lord, and shield me from the storms that rage within.
Psalm 46:1
“God is our refuge and strength, an ever-present help in trouble.” Be my refuge in this difficult season. Amen.
13. Bible Verse for Healing of the Heart
Dear Lord, my heart aches under the weight of depression. I ask for Your healing touch upon my heart. Mend the broken pieces, and restore joy where sorrow has taken root. I trust in Your power to heal and bring new life to the places that feel desolate within me.
Psalm 147:3
“He heals the brokenhearted and binds up their wounds.” Heal my broken heart, Lord. Amen.
14. Bible Verse for Patience in the Process
Lord, this season of depression feels never-ending, and I grow impatient for healing. Teach me patience as I wait on Your timing. Remind me that You are at work, even when I cannot see it. Give me the grace to endure this journey, trusting that You will bring me through it in Your perfect time.
Romans 12:12
“Be joyful in hope, patient in affliction, faithful in prayer.” Help me to wait on You with patience and trust. Amen.
15. Bible Verse for God’s Strength in Weakness
Father, I feel weak and unable to carry the burdens of my life right now. But I know that Your strength is made perfect in my weakness. Grant me the strength to continue, not in my own power but in Yours. Be the source of my endurance, and lift me up when I falter.
2 Corinthians 12:9
“My grace is sufficient for you, for my power is made perfect in weakness.” Lord, strengthen me in my weakness. Amen.
16. Bible Verse for Renewed Hope
Dear Lord, my hope feels depleted, and despair weighs heavily on my heart. I ask that You renew my hope in You. Show me that even in my darkest moments, You are still working for my good. Help me to see beyond the pain and hold onto the hope of better days ahead, rooted in Your promises.
Romans 15:13
“May the God of hope fill you with all joy and peace as you trust in him, so that you may overflow with hope by the power of the Holy Spirit.” Renew my hope, Lord, by Your Spirit. Amen.
17. Bible Verse for Overcoming Fear
Lord, depression often brings fear into my heart—fear of the unknown, fear of failure, fear of tomorrow. Help me overcome these fears by trusting in Your power and goodness. Remind me that You have not given me a spirit of fear, but of love, power, and a sound mind.
2 Timothy 1:7
“For the Spirit God gave us does not make us timid, but gives us power, love and self-discipline.” Grant me courage to face my fears. Amen.
18. Bible Verse for God’s Light in Darkness
Dear Lord, depression feels like a thick darkness surrounding me. Yet, I know that You are the light that shines in the darkness, and the darkness cannot overcome You. Shine Your light upon my soul, Lord, and drive away the shadows of despair. Help me to walk in Your light, trusting that You will guide me.
John 1:5
“The light shines in the darkness, and the darkness has not overcome it.” Be the light in my darkness, Lord. Amen.
19. Bible Verse for God’s Unfailing Love
Father, in my darkest times, it feels as though love is out of reach. Yet, Your love never fails and never abandons me. Help me to grasp the depth of Your love for me, even when I feel unworthy. Fill my heart with the assurance that Your love surrounds me always, even in my depression.
Psalm 136:1
“Give thanks to the Lord, for he is good. His love endures forever.” Thank You for Your unfailing love, Lord. Amen.
20. Bible Verse for Joy in the Lord
Lord, I long for joy that transcends my circumstances. Help me to find joy in You, even when depression weighs heavy on my heart. Remind me that my joy comes from knowing You, and that nothing can take that joy away. Renew my heart with Your joy, and let it be my strength in this difficult season.
Nehemiah 8:10
“Do not grieve, for the joy of the Lord is your strength.” Fill my heart with Your joy, Lord. Amen.
21. Bible Verse for God’s Faithfulness
Heavenly Father, depression makes me doubt so much, but I hold onto the truth that You are always faithful. Even when I struggle to see Your goodness, help me remember Your faithfulness throughout my life. Strengthen my faith in Your steadfast love, and let me rest in the assurance that You will never leave me.
Lamentations 3:22-23
“Because of the Lord’s great love we are not consumed, for his compassions never fail. They are new every morning; great is your faithfulness.” I trust in Your faithfulness, Lord. Amen.
22. Bible Verse for Divine Guidance
Father, I feel lost in the fog of depression and unsure of which way to turn. I ask for Your divine guidance to lead me out of this darkness. Help me to trust in Your direction, knowing that You guide me with love and purpose. Show me the path You have prepared for me, and help me follow it with confidence.
Psalm 32:8
“I will instruct you and teach you in the way you should go; I will counsel you with my loving eye on you.” Guide me with Your wisdom, Lord. Amen.
23. Bible Verse for God’s Sovereignty
Lord, my heart feels overwhelmed, but I know that You are sovereign over all. Help me to remember that nothing in my life is outside of Your control. Give me peace as I surrender my situation to You, knowing that You are working all things for my good, even when I cannot see it.
Romans 8:28
“And we know that in all things God works for the good of those who love him, who have been called according to his purpose.” I trust in Your sovereignty, Lord. Amen.
24. Bible Verse for God’s Presence in Trials
Dear Lord, depression feels like a never-ending trial, but I trust that You are with me in the midst of it. Help me to feel Your presence, especially when I am overwhelmed by sadness. Remind me that You walk beside me through every trial, and that I will never face any hardship alone.
Isaiah 43:2
“When you pass through the waters, I will be with you; and when you pass through the rivers, they will not sweep over you.” Thank You for being with me in every trial, Lord. Amen.
25. Bible Verse for Endurance in the Storm
Father, depression feels like a storm that I cannot escape. But I ask for Your strength to endure this storm with faith and perseverance. Help me to hold onto You when the winds rage and the waters rise. Be my anchor, and remind me that You are the one who calms the storm.
James 1:12
“Blessed is the one who perseveres under trial because, having stood the test, that person will receive the crown of life that the Lord has promised to those who love him.” Strengthen me to endure this storm, Lord. Amen.
26. Bible Verse for Peace Beyond Understanding
Lord, my heart is troubled, and peace seems elusive in the midst of depression. Yet I know that You offer peace that surpasses all understanding. I ask for Your peace to calm my anxious thoughts and bring stillness to my soul. Help me to rest in Your presence, trusting that You are with me always.
Philippians 4:7
“And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus.” Fill me with Your peace, Lord. Amen.
27. Bible Verse for Trusting God’s Plan
Father, depression makes me question everything, including Your plan for my life. Help me to trust that You have a purpose for this pain, even when I cannot understand it. Guide me to place my hope in Your plan and not in my own understanding. I trust that You are leading me to something greater.
Proverbs 3:5-6
“Trust in the Lord with all your heart and lean not on your own understanding; in all your ways submit to him, and he will make your paths straight.” Help me trust Your plan, Lord. Amen.
28. Bible Verse for Comfort in Affliction
Lord, I am afflicted by the weight of depression, but I know that You are my comforter. I ask for Your comfort to fill my heart and ease the pain I feel. Surround me with Your love, and help me to find solace in Your presence. Let Your comfort bring healing and hope to my weary soul.
2 Corinthians 1:3-4
“Praise be to the God and Father of our Lord Jesus Christ, the Father of compassion and the God of all comfort, who comforts us in all our troubles.” Comfort me in my affliction, Lord. Amen.
29. Bible Verse for Redemption from Despair
Father, depression feels like a pit from which I cannot escape, but I believe that You are my redeemer. Lift me out of this pit, Lord, and restore my life with joy and purpose. Redeem the days that depression has stolen from me, and help me walk forward in the freedom You offer.
Psalm 103:4
“Who redeems your life from the pit and crowns you with love and compassion.” Redeem my life, Lord, from despair. Amen.
30. Bible Verse for Joy Restored
Lord, my joy has been stripped away by depression, but I believe that You can restore it. Fill me once again with joy that comes from knowing You and walking in Your love. Restore to me the joy of Your salvation, and let it be my strength in the midst of this struggle.
Psalm 51:12
“Restore to me the joy of your salvation and grant me a willing spirit, to sustain me.” Restore my joy, Lord. Amen.
Conclusion
Depression can be an isolating and difficult journey, but the Bible offers an unshakable source of hope and healing. Throughout Scripture, God reminds us that He is near to the brokenhearted, providing strength, comfort, and the promise of restoration. As you have prayed through these verses, may you be reminded that no matter how deep your pain, God’s love reaches even deeper.
The prayers and Bible verses shared in this article are meant to guide you toward God’s heart in moments of darkness. They remind you that depression does not define you, nor does it dictate the course of your life. God is always working, even when it feels as though nothing will change. He is a God of transformation, and He can bring peace, joy, and purpose back into your life.
As you continue to seek God in prayer, lean on His promises, and trust that He is your ever-present help in times of trouble. Allow His Word to speak life into your soul, renewing your strength and restoring your spirit. Hold onto the truth that God is for you, and He will carry you through this season. May you find healing, hope, and a renewed sense of joy as you walk forward, trusting in God’s unfailing love.
